Any specific part of Italy? First time?
This will the the fourth time to Italy. My first trip to Italy was in the late 1990's and all done by train. Flew into Zurich, took a train through the Alps and into Italy, started with 3 nights in Venice, but left after 2 because it was so expensive! So we added Pisa to our itinerary and were glad we did. We passed right by Firenze because at the time I didn't know that's Italian for Florence!! From there spent a few days in Rome, then train to Brindisi and ferry on to Greece.
Second trip we rented a car in Rome and spent 3 weeks visiting Umbria and Tuscany. It was our favorite trip ever. Orvieto, Spello, Assisi, Montepulciano, Pienza, Montalcino, Siena, Florence, Volterra, Luca, Pisa, Riomaggorie, and the amazing Civita di Bagnoregio.
Third trip I went alone and just spent a week in the tiny walled village of Monticchiello, a place near Pienza that we happened onto by accident on the previous trip, and I loved it so much I was determined to spend more time there. I did day drives in the countryside, looking for more unknown great places, but never found a place I liked as much as Monticchiello.
This time we're mainly going for the 7 night Croatia cruise, but we're going with friends who haven't been to Italy, so we're spending a couple of days in Rome, then train to Ancona on the east coast, where we'll get a car and spend a week at an agriturismo seeing eastern Italy, which I've not visited before. We can do day trips from there to see parts of Umbria I liked. Then we'll catch the ferry from Ancona to Split and start our Croatia cruise. So nice to be able to travel again!!